The neurotensin receptor 1 (NTR1) is overexpressed in many cancers, due to its role as a growth pathway. These NTR1-positive cancers include pancreatic, colon, prostate and breast cancers. In the radiopharmaceutical field, the overexpression of NTR1 in cancer has prompted the development of NTR1-targeted diagnostics and therapeutics. The neurotensin (NT) peptide exhibits low nanomolar affinity for NTR1 and has been the paradigm for NTR1-targeted agents. Since the 1980’s, radiolabeled NT analogs have been developed and evaluated for targeting NTR1-positive cancers. Since native NT is rapidly degraded in vivo by a variety of peptidases, a tremendous amount of effort has been put forth to design stabilized NT analogs with increased in vivo eff...
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles in the gro...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles in the gro...
Purpose: Neurotensin (NT) and its high affinity receptor (NTR1) are involved in several neoplastic p...
Neurotensin-receptor-1 (NTSR1) is regularly overexpressed in various cancers and contributes to the ...
Overexpression of the neurotensin receptor type 1 (NTS1R), a peptide receptor located at the plasma ...
The binding sequence of the regulatory peptide Neurotensin, NT(8-13), represents apromising tumour-s...
The neurotensin receptor 1 (NTR1) has been shown to be a promising target, due to its increased leve...
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been sugge...
A series of Gly-neurotensin(8-13) analogues modified at the N-terminus by acyclic tetraamines (Demot...
Background Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity a...
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been sugge...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been sugge...
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles in the gro...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles in the gro...
Purpose: Neurotensin (NT) and its high affinity receptor (NTR1) are involved in several neoplastic p...
Neurotensin-receptor-1 (NTSR1) is regularly overexpressed in various cancers and contributes to the ...
Overexpression of the neurotensin receptor type 1 (NTS1R), a peptide receptor located at the plasma ...
The binding sequence of the regulatory peptide Neurotensin, NT(8-13), represents apromising tumour-s...
The neurotensin receptor 1 (NTR1) has been shown to be a promising target, due to its increased leve...
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been sugge...
A series of Gly-neurotensin(8-13) analogues modified at the N-terminus by acyclic tetraamines (Demot...
Background Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity a...
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been sugge...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
Due to its expression in various malignant tumors, the neurotensin receptor 1 (NTS1R) has been sugge...
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles in the gro...
0001] The instant invention refers to in vivo stable branched peptides derived from the sequence of ...
Overexpression of neurotensin receptors (NTRs) has been suggested to play important roles in the gro...