MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFbeta2.

Choudhury, A.
Moniaux, N.
Ulrich, A. B.
Schmied, B. M.
Standop, J.
Pour, Parviz M.
Gendler, S. J.
Hollingsworth, Michael A.
Aubert, J-P
Batra, Surinder K.

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Publication date

February 2004

Publisher

DigitalCommons@UNMC

Language

English

Abstract

MUC4 is highly expressed in human pancreatic tumours and pancreatic tumour cell lines, but is minimally or not expressed in normal pancreas or chronic pancreatitis. Here, we investigated the aberrant regulation of MUC4 expression in vivo using clonal human pancreatic tumour cells (CD18/HPAF) grown either orthotopically in the pancreas (OT) or ectopically in subcutaneous tissue (SC) in the nude mice. Histological examination of the OT and SC tumours showed moderately differentiated and anaplastic morphology, respectively. The OT tumour cells showed metastases to distant lymph nodes and faster tumour growth (

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MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFbeta2.

Abstract

Extracted data

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFbeta2.

Abstract

Extracted data

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