Free fatty acids (FFA) induce hepatocyte lipoapoptosis by a c-Jun N-terminal kinase (JNK)-dependent mechanism. However, the cellular processes by which JNK engages the core apoptotic machinery during lipotoxicity, especially activation of BH3-only proteins, remain incompletely understood. Thus, our aim was to determine whether JNK mediates induction of BH3-only proteins during hepatocyte lipoapoptosis. The saturated FFA palmitate, but not the monounsaturated FFA oleate, induces an increase in PUMA mRNA and protein levels. Palmitate induction of PUMA was JNK1-dependent in primary murine hepatocytes. Palmitate-mediated PUMA expression was inhibited by a dominant negative c-Jun, and direct binding of a phosphorylated c-Jun containing the activ...
Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsatur...
Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the por...
Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. ...
BACKGROUND & AIMS: Saturated free fatty acids induce hepatocyte lipoapoptosis. This lipotoxicity inv...
The mechanisms of free fatty acid-induced lipoapoptosis are incompletely understood. Here we demonst...
13, 2011; doi:10.1152/ajpgi.00301.2011.—Isolated hepatocytes un-dergo lipoapoptosis, a feature of he...
Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in ...
Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) wit...
Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) wit...
Metabolic stress causes activation of the cJun NH2-terminal kinase (JNK) signal transduction pathway...
BACKGROUND: There are only few data relating the metabolic consequences of feeding diets very low in...
Metabolic stress causes activation of the cJun NH2-terminal kinase (JNK) signal transduction pathway...
BACKGROUND: Hepatitis C virus (HCV) infection and metabolic diseases including nonalcoholic steatohe...
BACKGROUND: In order to devise efficient treatments for complex, multi-factorial diseases, it is imp...
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic ste...
Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsatur...
Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the por...
Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. ...
BACKGROUND & AIMS: Saturated free fatty acids induce hepatocyte lipoapoptosis. This lipotoxicity inv...
The mechanisms of free fatty acid-induced lipoapoptosis are incompletely understood. Here we demonst...
13, 2011; doi:10.1152/ajpgi.00301.2011.—Isolated hepatocytes un-dergo lipoapoptosis, a feature of he...
Saturated free fatty acids (FFA) induce hepatocyte lipoapoptosis, a key mediator of liver injury in ...
Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) wit...
Recent studies have identified a cholestatic variant of nonalcoholic fatty liver disease (NAFLD) wit...
Metabolic stress causes activation of the cJun NH2-terminal kinase (JNK) signal transduction pathway...
BACKGROUND: There are only few data relating the metabolic consequences of feeding diets very low in...
Metabolic stress causes activation of the cJun NH2-terminal kinase (JNK) signal transduction pathway...
BACKGROUND: Hepatitis C virus (HCV) infection and metabolic diseases including nonalcoholic steatohe...
BACKGROUND: In order to devise efficient treatments for complex, multi-factorial diseases, it is imp...
Free fatty acid induction of inflammation and cell death is an important feature of nonalcoholic ste...
Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsatur...
Visceral adiposity in obesity causes excessive free fatty acid (FFA) flux into the liver via the por...
Nonalcoholic steatohepatitis (NASH) patients have elevated plasma saturated free fatty acid levels. ...