Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction...
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