Add to ORKGINTRODUCTION: We hypothesized that common Alzheimer\u27s disease (AD)-associated variants within the triggering receptor expressed on myeloid (TREM) gene cluster influence disease through gene expression. METHODS: Expression microarrays on temporal cortex and cerebellum from ∼400 neuropathologically diagnosed subjects and two independent RNAseq replication cohorts were used for expression quantitative trait locus analysis. RESULTS: A variant within a DNase hypersensitive site 5\u27 of TREM2, rs9357347-C, associates with reduced AD risk and increased TREML1 and TREM2 levels (uncorrected P = 6.3 × 10 DISCUSSION: Our findings point to rs9357347 as a functional regulatory variant that contributes to a protective effect observed at the TREM locu...
Background: Sequence variants, including the ε4 allele of apolipoprotein E, have been associated wit...
Loss‐of‐function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the r...
Alzheimer disease (AD) is known to be a predominantly sporadic late-onset disease, which increases i...
INTRODUCTION: We hypothesized that common Alzheimer\u27s disease (AD)-associated variants within the...
Introduction: We hypothesized that common Alzheimer's disease (AD)-associated variants within the tr...
The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor expressed on...
BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expres...
BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor express...
OBJECTIVES: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H)...
Abstract Alzheimer’s disease (AD) is the leading cause of dementia. The two histopathological marker...
Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of in...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Summary Alzheimer's disease is a genetically complex disorder; rare variants in the triggering rece...
AbstractTREM and TREM-like receptors are a structurally similar protein family encoded by genes clus...
TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on...
Background: Sequence variants, including the ε4 allele of apolipoprotein E, have been associated wit...
Loss‐of‐function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the r...
Alzheimer disease (AD) is known to be a predominantly sporadic late-onset disease, which increases i...
INTRODUCTION: We hypothesized that common Alzheimer\u27s disease (AD)-associated variants within the...
Introduction: We hypothesized that common Alzheimer's disease (AD)-associated variants within the tr...
The triggering receptor expressed on myeloid 2 (TREM2) is an immune phagocytic receptor expressed on...
BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor expres...
BACKGROUND: Homozygous loss-of-function mutations in TREM2, encoding the triggering receptor express...
OBJECTIVES: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H)...
Abstract Alzheimer’s disease (AD) is the leading cause of dementia. The two histopathological marker...
Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of in...
A coding missense mutation (rs3747742) in triggering receptor expressed on myeloid cell-like 2 (TREM...
Summary Alzheimer's disease is a genetically complex disorder; rare variants in the triggering rece...
AbstractTREM and TREM-like receptors are a structurally similar protein family encoded by genes clus...
TREM and TREM-like receptors are a structurally similar protein family encoded by genes clustered on...
Background: Sequence variants, including the ε4 allele of apolipoprotein E, have been associated wit...
Loss‐of‐function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the r...
Alzheimer disease (AD) is known to be a predominantly sporadic late-onset disease, which increases i...