実験的BLM肺線維症に関する放射線的研究

The process of experimental bleomycin (BLM) fibrosis of lungs was examined by means of lung scintigraphy in rats, and the agreement with histolgic or microangiographic features were evaluated. Rats were administrated 15mg/kg BLM 3 times a week, individually, and examinations were performed. Lung scintigraphy was taken after ^Tc labeled macroaggregated albumin (^Tc-MMA) was given in the vein and equilibrium was attained. Histologicaly, at 6 week after administration of BLM, collagen fiber formation was observed around vessels and bronchial tubes of the lungs and diaphragmatic pleura, and subsequently fibrosis progressed with the total ammount of BLM administered. The microangiographic findings, extension and/or stenosis of vessels was observed, and the capillary network was reduced, while decreased ^Tc-MMA uptake was observed as periferal lesions of the lungs in scintigram, especially at the bottom of the lungs. Both sets of findings were similar with the total ammount of BLM administration. In conclusion, it was suggested that the process of experimental. BLM fibrosis of lungs could be evaluated by lung scintigraphy in rats and that the findings would be parallel to histologic and microangiographic features