The increasing complexity of modern architectures and memory models challenges the design of optimizing compilers. It is mandatory to perform several optimizing transformations of the original program to exploit the machine to its best, especially for scientific, computational-intensive codes. Aiming at investigating the best transformation sequence and the best transformation parameters simultaneously, this paper presents a novel loop transformation framework, which integrates the advantages of polyhedral model and model-guided iterative compilation to create a powerful framework that is capable of fully automated non-parametric transformations and model-guided parametric transformations as well as automatic parameter search. The framework...