Chronic airway inflammation and airway hyperresponsiveness (AHR) are fundamental features leading to airway narrowing in bronchial asthma. Airway inflammation in asthmatics is characterized with the accumulation and activation of inflammatory cells such as eosinophils and mast cells, which is orchestrated by a network of Th2 cytokines, such as IL-4 and IL-5, released mainly from CD^+_4 T lymphocytes. The peptide hormone angiotensin II (AT II) plays an important role in the regulation of arterial blood pressure. Plasma levels of renin and AT II were reported to be elevated during acute exacerbation of asthma, and studies using type 1 AT II receptor (AT1) antagonist (ARE) suggested the involvement of the receptor in the pathogenesis of asthma...
The exact functional contribution of the various inflammatory cells, mediators, cytokines and growth...
Many patients suffering from asthma are not fully controlled by currently available treatments, and ...
RATIONALE: Th2 cytokines play an important role in allergic diseases. These cytokines activate signa...
Defective apoptosis of eosinophils, the main leukocyte in the pathogenesis of asthma, and delay in i...
Angiotensin-(1-7) [Ang-(1-7)]/Mas receptor pathway is currently recognized as a counterbalancing mec...
Asthma is a leading allergic disease worldwide, demonstrating an ever‑increasing prevalence over the...
The angiotensin-(1–7) [Ang-(1–7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory...
The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten ...
[[abstract]]The small GTPase RhoA and its downstream effectors are critical regulators in the pathop...
Asthma is a triad of intermittent airway obstruction, bronchial smooth muscle cell hyperreactivity t...
Half of all asthmatics suffer from allergic airway inflammation driven by type 2 immune responses in...
Rationale: IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerou...
Many patients suffering from asthma are not fully controlled by currently available treatments, and ...
The receptor for advanced glycation end products (RAGE) is a multiligand, cell surface receptor. Iso...
The mostly widely used bronchodilators in asthma therapy are β2-adrenoreceptor (β2AR) agonists, but ...
The exact functional contribution of the various inflammatory cells, mediators, cytokines and growth...
Many patients suffering from asthma are not fully controlled by currently available treatments, and ...
RATIONALE: Th2 cytokines play an important role in allergic diseases. These cytokines activate signa...
Defective apoptosis of eosinophils, the main leukocyte in the pathogenesis of asthma, and delay in i...
Angiotensin-(1-7) [Ang-(1-7)]/Mas receptor pathway is currently recognized as a counterbalancing mec...
Asthma is a leading allergic disease worldwide, demonstrating an ever‑increasing prevalence over the...
The angiotensin-(1–7) [Ang-(1–7)]/MAS1 receptor signaling axis is a key endogenous anti-inflammatory...
The prevalence of asthma has markedly increased in recent decades. Asthma affects approximately ten ...
[[abstract]]The small GTPase RhoA and its downstream effectors are critical regulators in the pathop...
Asthma is a triad of intermittent airway obstruction, bronchial smooth muscle cell hyperreactivity t...
Half of all asthmatics suffer from allergic airway inflammation driven by type 2 immune responses in...
Rationale: IL-9 is a pleiotropic cytokine that has multiple effects on structural as well as numerou...
Many patients suffering from asthma are not fully controlled by currently available treatments, and ...
The receptor for advanced glycation end products (RAGE) is a multiligand, cell surface receptor. Iso...
The mostly widely used bronchodilators in asthma therapy are β2-adrenoreceptor (β2AR) agonists, but ...
The exact functional contribution of the various inflammatory cells, mediators, cytokines and growth...
Many patients suffering from asthma are not fully controlled by currently available treatments, and ...
RATIONALE: Th2 cytokines play an important role in allergic diseases. These cytokines activate signa...