Use of a Single Intrauterine Insemination of Defrosted Cryopreserved Sperm for Therapeutic Donor Insemination.

OBJECTIVE: To evaluate the efficacy of a protocol employing defrosted cryopreserved sperm as a single well-timed intrauterine insemination. DESIGN: A retrospective observational study. SETTING: A university fertility service and a private fertility practice located in small metropolitan areas. PARTICIPANTS: All 138 donor sperm recipients (348 cycles) treated on this protocol by the author during a 27 month period were evaluated. All 86 patients (200 cycles) treated using intracervical inseminations bracketing the time of ovulation during the same time period were also evaluated. RESULTS: A single well-timed intrauterine insemination had an associated pregnancy rate of 13.8% per cycle. In contrast, intracervical inseminations bracketing the time of ovulation had an associated pregnancy rate of 5% per cycle (P \u3c .005). CONCLUSIONS: A single well-timed intrauterine insemination of defrosted cryopreserved sperm is more efficacious and less expensive than intracervical inseminations bracketing the time of ovulation