The human dentition is a typical diphyodont mammalian system with tooth replacement of most positions. However, after dental replacement and sequential molar development, the dental lamina undergoes apoptosis and fragments, leaving scattered epithelial units (dental lamina rests; DLRs). DLRs in adult humans are considered inactive epithelia, thought to possess limited capacity for further regeneration. However, we show that these tissues contain a small proportion of proliferating cells (assessed by both Ki67 and PCNA) but also express a number of common dental stem cell markers (Sox2, Bmi1, β-catenin and PH3) similar to that observed in many vertebrates that actively, and continuously regenerate their dentition. We compared these human tis...
Sharks and rays (elasmobranchs) have the remarkable capacity to continuously regenerate their teeth....
Stem cell biology has become an important field in regenerative medicine and tissue engineering ther...
Stem cells are undifferentiated cells, capable of renewing themselves, with the capacity to produce ...
The human dentition is a typical diphyodont mammalian system with tooth replacement of most positio...
The enthralling ability to continuously replace teeth throughout life has fascinated scientists for ...
The appearance of toothed vertebrates has proven a major determinant of the overall success of this ...
Thesis (Ph.D.)--University of Washington, 2022Tooth enamel secreted by ameloblasts is the hardest ma...
Sharks and rays (elasmobranchs) regenerate their teeth via a novel system in which multiple teeth de...
AbstractIn many non-mammalian vertebrates, adult dentitions result from cyclical rounds of tooth reg...
Deep understanding of tooth regeneration is hampered by the lack of lifelong replacing oral dentitio...
The evolution of oral teeth is considered a major contributor to the overall success of jawed verteb...
BackgroundVertebrate teeth exhibit a wide range of regenerative systems. Many species, including mos...
AbstractThe evolution of oral teeth is considered a major contributor to the overall success of jawe...
For centuries, scientists have known that certain animals can regenerate missing parts of their bodi...
Science and medicine have progressed in unfathomable ways over the past century. Paradoxically, as o...
Sharks and rays (elasmobranchs) have the remarkable capacity to continuously regenerate their teeth....
Stem cell biology has become an important field in regenerative medicine and tissue engineering ther...
Stem cells are undifferentiated cells, capable of renewing themselves, with the capacity to produce ...
The human dentition is a typical diphyodont mammalian system with tooth replacement of most positio...
The enthralling ability to continuously replace teeth throughout life has fascinated scientists for ...
The appearance of toothed vertebrates has proven a major determinant of the overall success of this ...
Thesis (Ph.D.)--University of Washington, 2022Tooth enamel secreted by ameloblasts is the hardest ma...
Sharks and rays (elasmobranchs) regenerate their teeth via a novel system in which multiple teeth de...
AbstractIn many non-mammalian vertebrates, adult dentitions result from cyclical rounds of tooth reg...
Deep understanding of tooth regeneration is hampered by the lack of lifelong replacing oral dentitio...
The evolution of oral teeth is considered a major contributor to the overall success of jawed verteb...
BackgroundVertebrate teeth exhibit a wide range of regenerative systems. Many species, including mos...
AbstractThe evolution of oral teeth is considered a major contributor to the overall success of jawe...
For centuries, scientists have known that certain animals can regenerate missing parts of their bodi...
Science and medicine have progressed in unfathomable ways over the past century. Paradoxically, as o...
Sharks and rays (elasmobranchs) have the remarkable capacity to continuously regenerate their teeth....
Stem cell biology has become an important field in regenerative medicine and tissue engineering ther...
Stem cells are undifferentiated cells, capable of renewing themselves, with the capacity to produce ...