Enabled by a growing understanding of its genetic origins, modern medicine is increasingly moving towards prevention rather than treatment of disease. Notable innovations, such as genome editing, can impact medicine only in the context of extensive knowledge of human genetics. Yet it was recently discovered that a phenomenon called “alternative reading frame” (ARF) genes appears in the human genome far more commonly than was thought possible. Exons, the coding portion of DNA, are transcribed into RNA sequences consisting of groupings of three nucleotides called codons. Codons correspond to particular amino acids, and the chain of translated amino acids form a protein based on which exons are included. Unlike non-ARF genes, in ARFs one exon ...
Accurate annotation of protein coding regions is essential for understanding how genetic information...
<div><p>A fully mature mRNA is usually associated to a reference open reading frame encoding a singl...
A complete and accurate set of human protein-coding gene annotations is perhaps the single most impo...
Enabled by a growing understanding of its genetic origins, modern medicine is increasingly moving to...
Genes are comprised of exons, which are encoded in groups of three called codons. Each codon corresp...
Our goal was to identify evolutionary conserved frame transitions in protein coding regions and to u...
Human gene catalogs are fundamental to the study of human biology and medicine. But they are all bas...
<div><p>Human gene catalogs are fundamental to the study of human biology and medicine. But they are...
<p>A) Distribution of known mutant origins across viral ARF sequences attributable to a particular c...
Ribosome profiling (Ribo-seq) has catalyzed a paradigm shift in our understanding of the translation...
This report presents systematic empirical annotation of transcript products from 399 annotated prote...
Abstract: In many eukaryotic messenger ribonucleic acids (mRNAs) one or more short upstream open rea...
A fully mature mRNA is usually associated to a reference open reading frame encoding a single protei...
Recent evidence from proteomics and deep massively parallel sequencing studies have revealed that eu...
Human gene catalogs are fundamental to the study of human biology and medicine. But they are all bas...
Accurate annotation of protein coding regions is essential for understanding how genetic information...
<div><p>A fully mature mRNA is usually associated to a reference open reading frame encoding a singl...
A complete and accurate set of human protein-coding gene annotations is perhaps the single most impo...
Enabled by a growing understanding of its genetic origins, modern medicine is increasingly moving to...
Genes are comprised of exons, which are encoded in groups of three called codons. Each codon corresp...
Our goal was to identify evolutionary conserved frame transitions in protein coding regions and to u...
Human gene catalogs are fundamental to the study of human biology and medicine. But they are all bas...
<div><p>Human gene catalogs are fundamental to the study of human biology and medicine. But they are...
<p>A) Distribution of known mutant origins across viral ARF sequences attributable to a particular c...
Ribosome profiling (Ribo-seq) has catalyzed a paradigm shift in our understanding of the translation...
This report presents systematic empirical annotation of transcript products from 399 annotated prote...
Abstract: In many eukaryotic messenger ribonucleic acids (mRNAs) one or more short upstream open rea...
A fully mature mRNA is usually associated to a reference open reading frame encoding a single protei...
Recent evidence from proteomics and deep massively parallel sequencing studies have revealed that eu...
Human gene catalogs are fundamental to the study of human biology and medicine. But they are all bas...
Accurate annotation of protein coding regions is essential for understanding how genetic information...
<div><p>A fully mature mRNA is usually associated to a reference open reading frame encoding a singl...
A complete and accurate set of human protein-coding gene annotations is perhaps the single most impo...