An Giang province is located in the Mekong Delta of Vietnam, recognized as Vietnam’s Mecca for large Muslim population in Vietnam. This paper introduces the root of the Cham (Sunni) Muslims living in this southwestern part of Vietnam. The historical research and documentary research (in which relevant historical documents and articles were selected to review and comment) were utilized in the study. The paper shows some differences between the Cham Muslims in this region and the Hindu Chams (Balamon). More importantly, this paper indicates that the Chams in the Mekong Delta have had more mobile ways of life and a more highly regional integration in the ASEAN Community and a larger Muslim world rather than other Cham groups in Vietnam