Abstract Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an underlying disturbance of sensory excitability due to changes in ion conductance. The present study addresses the potassium channel subunit gene KCNE3 as a potential candidate for tinnitus susceptibility. 288 Caucasian outpatients with a diagnosis of chronic tinnitus were systematically screened for mutations in the KCNE3 open reading frame and in the adjacent region by direct sequencing. Allele frequencies were determined for 11 known variants of which two (F66F and R83H) were polymorphic but were not associated with the disorder. No novel variants were identified and only three carriers of R83H were noted. However, owing to a lack ...
AbstractPotassium channels regulate electrical signaling and the ionic composition of biological flu...
Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked t...
Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is reported by...
Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an ...
Chronic tinnitus is a highly prevalent and often incapacitating condition frequently associated with...
Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom s...
Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom s...
KCNQ4 is frequently mutated in autosomal dominant non-syndromic hearing loss (NSHL), a typically lat...
Tinnitus, the perception of phantom sound, is often a debilitating condition that affects many milli...
There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode e...
tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic,...
Meniere's disease (MD) is a complex disease of unknown etiology characterized by a symptomatic tetra...
Subjective tinnitus is the perception of sound in the absence of external or bodily-generated sounds...
peer reviewedBackground: tinnitus is a heterogeneous condition associated with audio logical and/or ...
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general populat...
AbstractPotassium channels regulate electrical signaling and the ionic composition of biological flu...
Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked t...
Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is reported by...
Membrane-stabilizing drugs have long been used for the treatment of chronic tinnitus, suggesting an ...
Chronic tinnitus is a highly prevalent and often incapacitating condition frequently associated with...
Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom s...
Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom s...
KCNQ4 is frequently mutated in autosomal dominant non-syndromic hearing loss (NSHL), a typically lat...
Tinnitus, the perception of phantom sound, is often a debilitating condition that affects many milli...
There are twenty-five known inherited cardiac arrhythmia susceptibility genes, all of which encode e...
tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic,...
Meniere's disease (MD) is a complex disease of unknown etiology characterized by a symptomatic tetra...
Subjective tinnitus is the perception of sound in the absence of external or bodily-generated sounds...
peer reviewedBackground: tinnitus is a heterogeneous condition associated with audio logical and/or ...
Tinnitus is the perception of a phantom sound that affects between 10 and 15% of the general populat...
AbstractPotassium channels regulate electrical signaling and the ionic composition of biological flu...
Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked t...
Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is reported by...