Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis
- McGrath, Emmet E
- Lawrie, Allan
- Marriott, Helen M
- Mercer, Paul
- Cross, Simon S
- Arnold, Nadine
- Singleton, Vanessa
- Thompson, Alfred A R
- Walmsley, Sarah R
- Renshaw, Stephen A
- Sabroe, Ian
- Chambers, Rachel C
- Dockrell, David H
- Whyte, Moira K B
Publication date
January 2012
DOIAbstract
The death receptor ligand tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) shows considerable clinical promise as a therapeutic agent. TRAIL induces leukocyte apoptosis, reducing acute inflammatory responses in the lung. It is not known whether TRAIL modifies chronic lung injury or whether TRAIL has a role in human idiopathic pulmonary fibrosis (IPF). We therefore explored the capacity of TRAIL to modify chronic inflammatory lung injury and studied TRAIL expression in patients with IPF
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