EFFECTS OF SULPIRIDE-INDUCED D2 DOPAMINE RECEPTOR BLOCKADE ON IMMUNE RESPONSIVENESS OF RATS

The involvement of catecholamine receptors (D2 dopamine) was investigated in restraint stress, influence immune system, with concomitant changes in immune response. Adults rats pretreated once with LPS (a bacterial product) (25μg/250μl, i.p.), produce an immune response, were subjected to i.p. injection with sulpiride (4 mg/kg b.w., i.p.), a selective antagonist for D2 dopamine receptors, after 3 days postimmunization. After 18 days later, we assessed the total protein number, antibody titer, lymphocyte number and albumin/globulin ratio. In summary, we provide that D2 dopamine receptor blockade impaired immune responsiveness in restraint stress