Assessment of Certain Biochemical Parameters among Petrol Station Workers in Sana’a City, Yemen

Objective: To assess hepatic and renal functions among petrol stations workers in Sana’a city, Yemen. Methods: A case-control study was carried out in Sana’a city, in the period from November 2017 to April 2018. Cases included 109 eligible petrol station workers exposed to petrol for at least six hours daily over a period of six months or more, while 109 apparently healthy office workers were recruited from the University of Science and Technology as controls. Data were collected using a pre-designed questionnaire through face-to-face interview. Then, blood samples were collected from cases and controls and tested for albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea and creatinine in the Laboratory Department of the University of Science and Technology Hospital. Data were analyzed using SPSS, version 23.0. Results: The mean concentration of serum albumin among petrol station workers was significantly lower than the controls. In contrast, the mean level of serum ALP was significantly higher among the petrol station workers than the controls. On the other hand, there were no statistically significant differences in the mean levels of serum ALT and AST between the two groups. Although the mean concentrations of creatinine and urea were higher among the controls than the petrol station workers, the difference was only significantly higher for creatinine among office workers. Conclusions: Although no specific biochemical abnormalities exist in the hepatic and renal functions of petrol station workers in Sana’a city, these parameters may show evident effects with prolonged exposure to petrol components. Further longitudinal studies with larger sample sizes, longer durations of exposure and regular follow-up are recommended to assess the impact of long-term exposure to petrol on hepatic and renal functions