Dynamics of telomere length and mitochondrial DNA content in a cohort study of HIV-infected and HIV-uninfected pregnant women and cell culture models

Sara , Saberi

Publication date

January 2018

Publisher

University of British Columbia

Abstract

Globally, women constitute around 50% of HIV-infected individuals. While mother-to-child transmission accounts for 90% of new HIV infections among children, combination antiretroviral therapy (cART) reduces the risk from 25% to <2%. Treatment guidelines now promote lifelong cART for all persons living with HIV. This implies that more women will be conceiving on cART and exposing their unborn child over a longer period. Nucleoside reverse transcriptase inhibitors can have off target effects. These drugs can inhibit reverse transcriptase activity of telomerase, which could lead to a shortening of leukocyte telomere length (LTL). LTL has been described as a marker of cellular aging and a predictor of age-related diseases over time. Several ant...

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Dynamics of telomere length and mitochondrial DNA content in a cohort study of HIV-infected and HIV-uninfected pregnant women and cell culture models

Abstract

Extracted data

Dynamics of telomere length and mitochondrial DNA content in a cohort study of HIV-infected and HIV-uninfected pregnant women and cell culture models

Abstract

Extracted data

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