Brain region-specific DNA methylation and chromatin accessibility

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal and abnormal brain function involve specialized brain regions, yet little is known about brain region-specific epigenetic differences We study DNA methylation and chromatin accessibility in multiple brain regions of the normal human brain using whole-genome bisulfite sequencing and ATAC sequencing. Flow sorting reveals differences between neuronal and glial cells, as well as between brain regions. We show that differences in DNA methylation and accessibility between brain regions are enriched for explained heritability of multiple neurological traits.Non UBCUnreviewedAuthor affiliation: John Hopkins UniversityFacult