No differences in clinical outcomes with the addition of viral load testing to CD4 cell count monitoring among HIV infected participants receiving ART in rural Uganda: Long-term results from the Home Based AIDS Care Project
- Okoboi, Stephen
- Ekwaru, Paul J
- Campbell, James D
- Egessa, Aggrey
- King, Racheal
- Bakanda, Celestin
- Muramuzi, Emmy
- Kaharuza, Frank
- Malamba, Samuel
- Moore, David M
Publication date
February 2016
DOI Publisher
Springer Science and Business Media LLCAbstract
Background: We compared clinical outcomes among HIV-infected participants receiving ART who were randomized to viral load (VL) and CD4 cell count monitoring in comparison to CD4 cell count monitoring alone in Tororo, Uganda. Methods Beginning in May 2003, participants with CD4 cell counts <250 cells/μL or WHO stage 3 or 4 disease were randomized to clinical monitoring alone, clinical monitoring plus quarterly CD4 cell counts (CD4-only); or clinical monitoring, quarterly CD4 cell counts and quarterly VL testing (CD4-VL). In 2007, individuals in clinical monitoring arm were re-randomized to the other two arms and all participants were followed until March 31, 2...
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