We evaluated the effects of mini-strokes targeted to individual pial arterioles on motor and cortical function within the first hours after ischemia. This was done in Thy-1 line 18 channelrhodopsin-2 (ChR2) transgenic mice. Using optogenetics, we directly assessed both the excitability and motor output of cortical neurons in a rapid, repeated, and relatively non-invasive manner independent of behavioral state or training. Occlusion of individual arterioles within the motor cortex led to a ministroke that was verified using laser speckle contrast imaging. Surprisingly, ministrokes targeted to a relatively small region of the forelimb motor map, with an ischemic core of 0.07 ± 0.03 mm², impaired motor responses evoked from points across wide...
International audienceDays and weeks after an ischemic stroke, the peri-infarct area adjacent to the...
International audienceDays and weeks after an ischemic stroke, the peri-infarct area adjacent to the...
Purpose Limited restoration of function is known to occur spontaneously after an ischemic injury to ...
We evaluated the effects of mini-strokes targeted to individual pial arterioles on motor and cortica...
ABSTRACT OF THE DISSERTATIONLarge-scale spatiotemporal neuronal activity dynamics predict cortical v...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
The motor cortex controls voluntary, skilled movements. It possesses a basic somatotopic organizatio...
The motor cortex controls voluntary, skilled movements. It possesses a basic somatotopic organizatio...
Understanding circuit-level manipulations that affect the brain’s capacity for plasticity will infor...
Understanding circuit-level manipulations that affect the brain’s capacity for plasticity will infor...
Background and Purpose-Failure of prompt motor recovery after spontaneous recirculation or thromboly...
International audienceDays and weeks after an ischemic stroke, the peri-infarct area adjacent to the...
International audienceDays and weeks after an ischemic stroke, the peri-infarct area adjacent to the...
Purpose Limited restoration of function is known to occur spontaneously after an ischemic injury to ...
We evaluated the effects of mini-strokes targeted to individual pial arterioles on motor and cortica...
ABSTRACT OF THE DISSERTATIONLarge-scale spatiotemporal neuronal activity dynamics predict cortical v...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
Purpose: Limited restoration of function is known to occur spontaneously after an ischemic injury to...
The motor cortex controls voluntary, skilled movements. It possesses a basic somatotopic organizatio...
The motor cortex controls voluntary, skilled movements. It possesses a basic somatotopic organizatio...
Understanding circuit-level manipulations that affect the brain’s capacity for plasticity will infor...
Understanding circuit-level manipulations that affect the brain’s capacity for plasticity will infor...
Background and Purpose-Failure of prompt motor recovery after spontaneous recirculation or thromboly...
International audienceDays and weeks after an ischemic stroke, the peri-infarct area adjacent to the...
International audienceDays and weeks after an ischemic stroke, the peri-infarct area adjacent to the...
Purpose Limited restoration of function is known to occur spontaneously after an ischemic injury to ...