Cells in multicellular organisms are arranged in complex three-dimensional patterns. To achieve such complexity, cells must form adhesive contacts with the extracellular matrix (ECM). The most common adhesion receptors that mediate cell-ECM adhesions are the integrins. A large cytoplasmic network of proteins, namely the integrin adhesion complex (IAC) is recruited to the site of adhesions. Regulated assembly and disassembly, or turnover, of the IAC is essential for dynamic cell movements and tissue maintenance. In this project, I sought to investigate the role of mechanical force on the turnover of talin, a core component of the IAC and an essential linker between integrins and the actin cytoskeleton. To investigate the turnover of talin i...
Cell adhesion to the extracellular matrix (ECM), mediated by transmembranereceptors of the integrin ...
Talin protein is one of the key components in integrin-mediated adhesion complexes. Talins transmit ...
Cells in developing organisms are subjected to particular mechanical forces that shape tissues and i...
Cell-extra cellular matrix (ECM) adhesion through the integrin family of receptors is required for m...
Morphogenesis is the process by which cells rearrange to form complex three dimensional structures. ...
The morphogenesis and maintenance of three-dimensional tissue architecture requires intricate, coord...
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellula...
During the morphogenesis of multicellular organisms, cells undergo rearrangements and morphological ...
Cells adhere to the surrounding tissue and probe its mechanical properties by forming cell-matrix ad...
Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and enabling cell...
A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing prot...
Cells sense their environment and adhere to substrates with the help of cell surface receptors,integ...
Attachment of cells to the Extracellular Matrix (ECM) via integrins is essential for animal developm...
Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the ...
Cells adhere to the surrounding tissue and probe its mechanical properties by forming cell-matrix ad...
Cell adhesion to the extracellular matrix (ECM), mediated by transmembranereceptors of the integrin ...
Talin protein is one of the key components in integrin-mediated adhesion complexes. Talins transmit ...
Cells in developing organisms are subjected to particular mechanical forces that shape tissues and i...
Cell-extra cellular matrix (ECM) adhesion through the integrin family of receptors is required for m...
Morphogenesis is the process by which cells rearrange to form complex three dimensional structures. ...
The morphogenesis and maintenance of three-dimensional tissue architecture requires intricate, coord...
Talin has emerged as the key cytoplasmic protein that mediates integrin adhesion to the extracellula...
During the morphogenesis of multicellular organisms, cells undergo rearrangements and morphological ...
Cells adhere to the surrounding tissue and probe its mechanical properties by forming cell-matrix ad...
Cell-matrix adhesion is essential for building animals, promoting tissue cohesion, and enabling cell...
A fundamental question in mechanobiology is how mechanical stimuli are sensed by mechanosensing prot...
Cells sense their environment and adhere to substrates with the help of cell surface receptors,integ...
Attachment of cells to the Extracellular Matrix (ECM) via integrins is essential for animal developm...
Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion, links the ...
Cells adhere to the surrounding tissue and probe its mechanical properties by forming cell-matrix ad...
Cell adhesion to the extracellular matrix (ECM), mediated by transmembranereceptors of the integrin ...
Talin protein is one of the key components in integrin-mediated adhesion complexes. Talins transmit ...
Cells in developing organisms are subjected to particular mechanical forces that shape tissues and i...