Add to ORKGThis dissertation describes synthetic efforts towards tetrodotoxin. Contact with tetrodotoxin brings upon paralytic shellfish poisoning (PSP) for the unfortunate victim. The syndrome can be fatal in extreme cases and symptoms include nausea, numbing of the lips and body, throat constriction, slurred speech, and loss of coordination. Our approach stems from the oxidative amidation of a phenol as a key step. This technology installs a necessary nitrogen-functionality of the natural product at an early stage; ultimately the route was optimized to allow the synthesis to proceed in a practical manner.Science, Faculty ofChemistry, Department ofGraduat
Small molecules that bind to voltage-gated sodium channels (VGSCs) are promising leads in the treatm...
Natural products can both challenge synthetic chemists and guide biologists. In this work, they prom...
This thesis details the application of two synthetic methodologies, developed by the Donohoe group, ...
This thesis covers a novel approach to tetrodotoxin that relies on the oxidative amidation of a phen...
This dissertation details a formal total synthesis of (±)-tetrodotoxin, a potent sodium channel bloc...
The invention provides for the synthesis of Tetrodotoxin, its tautomers, enantiomers, distercoisome...
The advanced intermediates in the syntheses of tetrodotoxin reported by Fukuyama, Alonso, and Sato ...
Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been...
A formal total synthesis of (±)-tetrodotoxin that relies on the bimolecular oxidative amidation of a...
This thesis describes chemoenzymatic formal total syntheses of tetrodotoxin and a concise synthetic ...
Oxidation of 1L-(1,2,3′,4,5/3,6)-3-hydroxymethyl-2,4,5-tri-O-methoxymethyl-3,3′-O-methylene-6-nitro-...
This dissertation describes two projects that focus on the synthesis of biologically active molecule...
Tetrodotoxin (TTX) is a deadly non-protein neurotoxin and a well-known sodium channel blocker, but i...
Paralytic shellfish toxins (PSTs) are a large group of marine biotoxins (~50 analogues), mainly prod...
Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and fatalities ea...
Small molecules that bind to voltage-gated sodium channels (VGSCs) are promising leads in the treatm...
Natural products can both challenge synthetic chemists and guide biologists. In this work, they prom...
This thesis details the application of two synthetic methodologies, developed by the Donohoe group, ...
This thesis covers a novel approach to tetrodotoxin that relies on the oxidative amidation of a phen...
This dissertation details a formal total synthesis of (±)-tetrodotoxin, a potent sodium channel bloc...
The invention provides for the synthesis of Tetrodotoxin, its tautomers, enantiomers, distercoisome...
The advanced intermediates in the syntheses of tetrodotoxin reported by Fukuyama, Alonso, and Sato ...
Tetrodotoxin (TTX) is a potent neurotoxin that was first identified in pufferfish but has since been...
A formal total synthesis of (±)-tetrodotoxin that relies on the bimolecular oxidative amidation of a...
This thesis describes chemoenzymatic formal total syntheses of tetrodotoxin and a concise synthetic ...
Oxidation of 1L-(1,2,3′,4,5/3,6)-3-hydroxymethyl-2,4,5-tri-O-methoxymethyl-3,3′-O-methylene-6-nitro-...
This dissertation describes two projects that focus on the synthesis of biologically active molecule...
Tetrodotoxin (TTX) is a deadly non-protein neurotoxin and a well-known sodium channel blocker, but i...
Paralytic shellfish toxins (PSTs) are a large group of marine biotoxins (~50 analogues), mainly prod...
Tetrodotoxin (TTX) is a potent neurotoxin responsible for many human intoxications and fatalities ea...
Small molecules that bind to voltage-gated sodium channels (VGSCs) are promising leads in the treatm...
Natural products can both challenge synthetic chemists and guide biologists. In this work, they prom...
This thesis details the application of two synthetic methodologies, developed by the Donohoe group, ...