We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression. This study investigates if specific AR phosphorylation sites have differing roles in the progression of hormone naïve prostate cancer (HNPC) to castrate resistant disease (CRPC). A panel of phosphospecific antibodies were employed to study AR phosphorylation in 84 matched HNPC and CRPC tumours. Immunohistochemistry measured Androgen receptor expression phosphorylated at serine residues 94 (pAR94), 308 (pAR308), 650(pAR650) and 791 (pAR791). No correlations with clinical parameters were observed for pAR94 or pAR650 in HNPC or CRPC tumours. In contrast to our previous observation with...
Background: Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domai...
Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may ...
The androgen receptor (AR) and its signaling pathway play an important role in the development and p...
We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and ma...
Background: Despite increases in diagnostics and effective treatments, over 300,000 men die from pr...
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via p...
Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostat...
SummaryThe androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the ...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Patients with advanced prostate cancer (PC) are usually treated with androgen withdrawal. While this...
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via p...
Background: Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domai...
Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may ...
The androgen receptor (AR) and its signaling pathway play an important role in the development and p...
We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and ma...
Background: Despite increases in diagnostics and effective treatments, over 300,000 men die from pr...
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via p...
Cell line studies demonstrate that the PI3K/Akt pathway is upregulated in hormone-refractory prostat...
SummaryThe androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the ...
The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the commone...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Prostate cancer (PC) remains a leading cause of cancer-related deaths among men worldwide, despite c...
Patients with advanced prostate cancer (PC) are usually treated with androgen withdrawal. While this...
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via p...
Background: Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domai...
Constitutively active androgen receptor variants (AR-V) lacking the ligand binding domain (LBD) may ...
The androgen receptor (AR) and its signaling pathway play an important role in the development and p...