Mononuclear phagocytes are important regulators and effectors of both the innate and acquired immune responses. Extensive research has highlighted an important role for phosphoinositides in monocyte cell regulation. The 3’-phosphoinositide metabolites produced by phosphatidylinositide 3-kinase (PI3K) family of lipid kinases are known to be involved in regulating numerous monocyte activities including phagocytosis, adherence, oxidative burst, and cytokine secretion. An important research objective is to develop an understanding of how specificity is achieved in PI3K signaling [i.e. PI3K signalling] for these diverse biological functions. The goal of this thesis was to determine when particular monocyte functional properties are governed by P...
The activation of antigen receptors triggers two important signalling pathways originating from phos...
The objective of this thesis has been to investigate the results of combined deficiencies of the 5' ...
The phosphoinositide 3-kinase (PI 3-kinase, PI3K) pathway transduces signals critical for lymphocyte...
Mononuclear phagocytes are important regulators and effectors of both the innate and acquired immune...
Deregulated production of cytokines, including IL-1beta, IL-6 and TNF plays an important role in chr...
Cytokines are secreted by cells of the immune system to coordinate immune responses. Lipopolysacchar...
AbstractPI3Ks regulate several key events in the inflammatory response to damage and infection. Ther...
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biologic...
PI3K are a family of lipid kinase enzymes that are involved in a broad spectrum of cellular, physiol...
Thesis (Ph.D.)--University of Washington, 2021p110δ, the catalytic subunit of phosphoinositide 3 kin...
There is hardly a cellular process that is not regulated in some way by phosphoinositides, which mak...
Mononuclear phagocyte activation enhances the functional properties of these cells, and endotoxin (...
<div><p>The innate immune system is the first line of host defense against infection and involves se...
This Article is brought to you for free and open access by the Biology at USF Scholarship Repository...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
The activation of antigen receptors triggers two important signalling pathways originating from phos...
The objective of this thesis has been to investigate the results of combined deficiencies of the 5' ...
The phosphoinositide 3-kinase (PI 3-kinase, PI3K) pathway transduces signals critical for lymphocyte...
Mononuclear phagocytes are important regulators and effectors of both the innate and acquired immune...
Deregulated production of cytokines, including IL-1beta, IL-6 and TNF plays an important role in chr...
Cytokines are secreted by cells of the immune system to coordinate immune responses. Lipopolysacchar...
AbstractPI3Ks regulate several key events in the inflammatory response to damage and infection. Ther...
Phosphoinositide 3-kinases (PI3Ks) are a family of enzymes that regulate a diverse array of biologic...
PI3K are a family of lipid kinase enzymes that are involved in a broad spectrum of cellular, physiol...
Thesis (Ph.D.)--University of Washington, 2021p110δ, the catalytic subunit of phosphoinositide 3 kin...
There is hardly a cellular process that is not regulated in some way by phosphoinositides, which mak...
Mononuclear phagocyte activation enhances the functional properties of these cells, and endotoxin (...
<div><p>The innate immune system is the first line of host defense against infection and involves se...
This Article is brought to you for free and open access by the Biology at USF Scholarship Repository...
Stimulation of macrophages by various ligands results in the activation of both phosphoinositide 3-k...
The activation of antigen receptors triggers two important signalling pathways originating from phos...
The objective of this thesis has been to investigate the results of combined deficiencies of the 5' ...
The phosphoinositide 3-kinase (PI 3-kinase, PI3K) pathway transduces signals critical for lymphocyte...