Werner syndrome is a human genetic disorder exhibiting a phenotype of premature senility with adolescent age of onset. Genetic analysis supported the hypothesis that Werner syndrome is a lesion in a single locus, WRN, assigned to the short arm of human chromosome 8 by genetic linkage to a polymorphic marker, D8S87 (Goto et al, 1992). The primary goal of this thesis was the structural and functional genomic characterization of WRN. The thesis consists of two parts. The first part undertook fine scale refinement of the genetic and physical map of the candidate genome interval from markers D8S87 to D8S137. The second part applied bioinformatics to the functional analysis of WRN through comparative sequence analysis of the DExH DNA heli...
Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development o...
Werner syndrome (WS) is a progeroid syndrome caused by autosomal recessive null mutations at the WRN...
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused b...
Werner syndrome is a human genetic disorder exhibiting a phenotype of premature senility with adole...
The Werner syndrome locus (WRN) is located at 8p11-p12. To facilitate eventual cloning of the WRN ge...
Werner syndrome (WS) is an autosomal recessive disorder characterized by the early onset of several ...
A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is characterized by th...
The International Registry of Werner syndrome ( www.wernersyndrome.org ) has been providing molecula...
Werner syndrome (WS) is a rare autosomal recessive disorder characterized by a constellation of adul...
Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although ...
Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the do...
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations...
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations...
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations...
The Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations ...
Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development o...
Werner syndrome (WS) is a progeroid syndrome caused by autosomal recessive null mutations at the WRN...
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused b...
Werner syndrome is a human genetic disorder exhibiting a phenotype of premature senility with adole...
The Werner syndrome locus (WRN) is located at 8p11-p12. To facilitate eventual cloning of the WRN ge...
Werner syndrome (WS) is an autosomal recessive disorder characterized by the early onset of several ...
A rare and autosomal recessive premature aging disorder, Werner syndrome (WS) is characterized by th...
The International Registry of Werner syndrome ( www.wernersyndrome.org ) has been providing molecula...
Werner syndrome (WS) is a rare autosomal recessive disorder characterized by a constellation of adul...
Werner syndrome is a progeroid disorder characterized by premature age-related phenotypes. Although ...
Aging is a natural and unavoidable part of life. However, aging is also the primary driver of the do...
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations...
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations...
Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by null mutations...
The Werner syndrome (WS) is an autosomal recessive segmental progeroid syndrome caused by mutations ...
Werner Syndrome (WS) is an autosomal recessive disorder characterized by the premature development o...
Werner syndrome (WS) is a progeroid syndrome caused by autosomal recessive null mutations at the WRN...
Werner syndrome (WS) is an autosomal recessive disease characterized by premature aging and caused b...
