The Notch receptor is part of a highly conserved signaling pathway shared in Drosophila, C. elegans and mammals. Extensive studies of Notch signaling have revealed its participation in the development of diverse organ systems including brain, blood cells, blood vessels, gut, and skin. Many genetic modifiers of the Notch signaling pathway have been identified, including some which act at the membrane and others in the nucleus. One such member is Deltex, an E3 ubiquitin ligase, which was originally identified as a modifier of Notch in a Drosophila genetic screen. In early lymphoid development, Deltex has been demonstrated functionally to antagonize Notch signaling but the precise molecular mechanism for this functional antagonism between Notc...
Notch signaling is a highly conserved pathway that plays numerous roles during cell fate decisions a...
The Notch signaling pathway is an evolutionary conserved mechanism to transmit signals upon ligand –...
textCell-cell communication events are crucial to determine the fate of each cell during development...
Notch is a developmental receptor, conserved in the evolution of the metazoa, which regulates cell f...
Notch proteins define a family of large receptors that mediate various cell fate decisions during de...
The Notch signaling pathway defines a conserved mechanism that regulates cell fate decisions in meta...
Kurtz (Krz) is the only Drosophila homolog of mammalian beta-arrestins. We have already implicated K...
During development, the Notch receptor regulates many cell fate decisions by a signaling pathway tha...
SummaryDSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular ...
AbstractThe Notch receptor mediates a short-range signal that regulates many cell fate decisions [1]...
The development of an organism is orchestrated by a small number of signaling pathways. In order to ...
International audienceNotch signaling is involved in numerous cellular processes during development ...
The evolutionarily conserved developmental pathway driven by Notch receptors and ligands has acquire...
AbstractBackground: Ligand-induced proteolytic cleavage and internalization of the plasma membrane r...
The Notch signaling pathway plays a central role in metazoan growth and patterning, and its deregula...
Notch signaling is a highly conserved pathway that plays numerous roles during cell fate decisions a...
The Notch signaling pathway is an evolutionary conserved mechanism to transmit signals upon ligand –...
textCell-cell communication events are crucial to determine the fate of each cell during development...
Notch is a developmental receptor, conserved in the evolution of the metazoa, which regulates cell f...
Notch proteins define a family of large receptors that mediate various cell fate decisions during de...
The Notch signaling pathway defines a conserved mechanism that regulates cell fate decisions in meta...
Kurtz (Krz) is the only Drosophila homolog of mammalian beta-arrestins. We have already implicated K...
During development, the Notch receptor regulates many cell fate decisions by a signaling pathway tha...
SummaryDSL ligands promote proteolysis of the Notch receptor, to release active Notch intracellular ...
AbstractThe Notch receptor mediates a short-range signal that regulates many cell fate decisions [1]...
The development of an organism is orchestrated by a small number of signaling pathways. In order to ...
International audienceNotch signaling is involved in numerous cellular processes during development ...
The evolutionarily conserved developmental pathway driven by Notch receptors and ligands has acquire...
AbstractBackground: Ligand-induced proteolytic cleavage and internalization of the plasma membrane r...
The Notch signaling pathway plays a central role in metazoan growth and patterning, and its deregula...
Notch signaling is a highly conserved pathway that plays numerous roles during cell fate decisions a...
The Notch signaling pathway is an evolutionary conserved mechanism to transmit signals upon ligand –...
textCell-cell communication events are crucial to determine the fate of each cell during development...