Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments - An In Vivo and Histology-Based Study.
- Ramasamy, Anantharaman
- Ng, Jaryl
- White, Stephen
- Johnson, Thomas W
- Foin, Nicolas
- Girard, Michael JA
- Dijkstra, Jouke
- Amersey, Rajiv
- Scoltock, Simon
- Koganti, Sudheer
- Jones, Daniel
- Jin, Chongying
- Räber, Lorenz
- Serruys, Patrick W
- Torii, Ryo
- Crake, Tom
- Rakhit, Roby
- Baumbach, Andreas
- Mathur, Anthony
- Bourantas, Christos V
DOIAbstract
BACKGROUND:Attenuation-compensated (AC) technique was recently introduced to improve the plaque characterization of optical coherence tomography (OCT). Histological validation demonstrated promising results but the efficacy and reproducibility of this technique for assessing in-vivo tissue composition remains unclear.Methods and Results:OCT images portraying native (n=200) and stented (n=200) segments and 31 histological cross-sections were analyzed. AC-OCT appeared superior to conventional (C)-OCT in detecting the external elastic lamina (EEM) borders (76% vs. 65.5%); AC-OCT enabled larger EEM arc detection compared with C-OCT (174.2±58.7° vs. 137.5±57.9°; P<0.001). There was poor agreement between the 2 techniques for detection of lipid i...
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