Hematobiochemical changes of lead Poisoning and amelioration with Ocimum sanctum in wistar albino rats

An experiment was carried out to study the hematobiochemical changes of chronic lead poisoning in adult male wistar albino rats for a period of twelve weeks. Adult 216 healthy rats were randomly divided into six groups viz. control (groupI), higher dose of lead acetate @60mgs/kg bwt (group II), Lower dose of lead acetate @ 30 mgs / kg bwt (group III), Higher dose of lead + Ocimum @ 400 mgs/ kg bwt (group IV), lower dose of lead + Ocimum @ 400 mgs/ kg bwt (group V), Ocimum control (group VI). All lead treated and ameliorated groups given Lead acetate/ lead + Ocimum orally for three days in a week for a period of twelve weeks. The mean PCV, Hb, values were reduced significantly (P<0.05) in lead treated rats as dose dependent manner. Where as significant improvement was noticed in Ocimum treated groups Increased TLC and PLC values as dose dependent manner. A significant reduction in PNC was noticed in ocimum treated groups. Significant (P<0.05) decrease in serum total protein values, serum glucose and increased creatinine values were observed in lead treated groups as dose dependent . Increased protein & glucose and decreased creatinine values obtained in Ocimum treated groups. The alterations in hematological and biochemical parameters in the present study indicates decreased lifespan & fragility of RBC and damage to liver, kidney and Pancreas in lead poisoned wistar albino rats. [Vet. World 2011; 4(6.000): 260-263