Study of Cgrp-Receptors in Human Isolated Middle Meningeal Arteries Using Bibn4096Bs, Compound 1, and HαCgrp(8-37)
- Z. Razzaque
- D. Shaw
- M. Bock
- L. Maskell
- J. Pickard
- D. Sirinathsinghji
- J. Longmore
Publication date
January 2001
DOI Publisher
Hindawi Limited Journal
The Scientific World JOURNALAbstract
Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1]. We investigated whether the antagonists BIBN4096BS[2], Compound 1 (WO98/11128, [3]), and CGRP(8-37) are functionally selective for CGRP receptors in human middle meningeal arteries (HMMA)
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