Add to ORKGWe investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arterial pressures and on pressor reactivity in 3-month-old male spontaneously hypertensive rats (SHR). Arterial blood pressure (BP) and pressor reactivity to phenylephrine (PHE) were investigated before and after 0.18 μg/kg ouabain administration (N = 6). The influence of hexamethonium (N = 6), canrenone (N = 6), enalapril (N = 6), and losartan (N = 6) on ouabain actions was evaluated. Ouabain increased BP (SAP: 137 ± 5.1 to 150 ± 4.7; DAP: 93.7 ± 7.7 to 116 ± 3.5 mmHg; P<0.05) but did not change PHE pressor reactivity. Hexamethonium reduced basal BP in control but not in ouabain-treated rats. However, hexamethonium + ouabain increased DAP ...
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plas...
1 Hypertension development, phenylephrine-induced contraction and Na+,K+-ATPase functional activity ...
Studies on the role of endogenous sodium pump inhibitors in hypertension have used ouabain, a Na,K-A...
We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arte...
Submitted by Morgana Andrade (morgana.andrade@ufes.br) on 2011-02-07T17:52:49Z No. of bitstreams: 2...
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The ef...
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The ef...
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The ef...
Objective Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normoten...
Objective Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normoten...
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been pro...
<div><p>Ouabain is a cardiac glycoside produced in the adrenal glands and hypothalamus. It affects t...
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been pro...
Abstract To assess whether chronic ouabain administration causes hypertension by increasing sympathe...
Male Sprague-Dawley rats were infused with 50 microg/kg/day of ouabain for 4 weeks to address the qu...
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plas...
1 Hypertension development, phenylephrine-induced contraction and Na+,K+-ATPase functional activity ...
Studies on the role of endogenous sodium pump inhibitors in hypertension have used ouabain, a Na,K-A...
We investigated the effects of low ouabain concentrations on systolic (SAP) and diastolic (DAP) arte...
Submitted by Morgana Andrade (morgana.andrade@ufes.br) on 2011-02-07T17:52:49Z No. of bitstreams: 2...
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The ef...
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The ef...
Ouabain increases vascular resistance and may induce hypertension by inhibiting the Na+ pump. The ef...
Objective Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normoten...
Objective Hypertensive rats are more sensitive to the pressor effects of acute ouabain than normoten...
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been pro...
<div><p>Ouabain is a cardiac glycoside produced in the adrenal glands and hypothalamus. It affects t...
Ouabain is an endogenous substance occurring in the plasma in the nanomolar range, that has been pro...
Abstract To assess whether chronic ouabain administration causes hypertension by increasing sympathe...
Male Sprague-Dawley rats were infused with 50 microg/kg/day of ouabain for 4 weeks to address the qu...
Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plas...
1 Hypertension development, phenylephrine-induced contraction and Na+,K+-ATPase functional activity ...
Studies on the role of endogenous sodium pump inhibitors in hypertension have used ouabain, a Na,K-A...