The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact
- van Dessel, L. (Lisanne)
- Riet, J. (Job) van
- Smits, M. (Minke)
- Zhu, Y. (Yanyun)
- Hamberg, A.P. (Paul)
- Heijden, M.S. (Michiel) van der
- Bergman, A.M. (Andries)
- Oort, I.M. (Inge) van
- Wit, R. (Ronald) de
- Voest, E.E. (Emile)
- Steeghs, N. (Neeltje)
- Yamaguchi, T.N. (Takafumi N.)
- Livingstone, J. (Julie)
- Boutros, P.C. (Paul C.)
- Martens, J.W.M. (John)
- Sleijfer, S. (Stefan)
- Cuppen, E. (Edwin)
- Zwart, W. (Wilbert)
- Werken, H.J.G. (Harmen) van de
- Mehra, N. (Niven)
- Lolkema, M.P. (Martijn)
Publication date
December 2019
DOI Publisher
Springer Science and Business Media LLCAbstract
Metastatic castration-resistant prostate cancer (mCRPC) has a highly complex genomic landscape. With the recent development of novel treatments, accurate stratification strategies are needed. Here we present the whole-genome sequencing (WGS) analysis of fresh-frozen metastatic biopsies from 197 mCRPC patients. Using unsupervised clustering based on genomic features, we define eight distinct genomic clusters. We observe potentially clinically relevant genotypes, including microsatellite ins
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