Glucose transporters (GLUT) are twelve-transmembrane spanning proteins that contain two pores capable of transporting glucose and dehydroascorbate in and out of cells. The mechanism by which transport is effected is unknown. An evolutionarily-based hypothesis for the mechanism of glucose transport is presented here based on reports that insulin has multiple binding sites for glucose. It is proposed that insulin-like peptides were incorporated as modular elements into transmembrane proteins during evolution, resulting in glucose transporting capacity. Homology searching reveals that all GLUT contain multiple copies of insulin-like regions. These regions map onto a model of GLUT in positions that define the glucose transport cores. This obser...
GLUT4 is a mammalian facilitative glucose transporter that is highly expressed in adipose tissue and...
In mammals requiring glucose as a primary energy source for the brain, blood glucose levels are tigh...
Glucose is a monosaccharide and fuel for body, it cannot pass through membrane by simple diffusion s...
AbstractThe glucose transporters (GLUT/SLC2A) are members of the major facilitator superfamily. Here...
helix Cellular uptake of glucose is a tightly controlled process. It is mediated by a family of intr...
BACKGROUND: GLUT4 is a predominant insulin regulated glucose transporter expressed in major glucose ...
GLUT4 is a predominant insulin regulated glucose transporter expressed in major glucose disposal tis...
This article discusses the mechanisms of membrane transport of glucose transporters. Glucose can be ...
Molecular dynamics simulations amounting to ≈8 μs demonstrate that the glucose transporter GLUT1 und...
Facilitative glucose transporters exhibit variable hexose affinity and tissue-specific expression. T...
In mammals, the transport of glucose across cell membranesoccurs by facilitated diffusion. Several c...
Insulin-regulated trafficking of the facilitative glucose transporter GLUT4 has been studied in many...
Despite being one of the first recognized targets of insulin action, the acceleration of glucose tra...
The glucose transporter 1 (GLUT1) belongs to the major facilitator superfamily (MFS) and is responsi...
There are two models of topology for the membrane domains of the erythrocyte/brain facilitative gluc...
GLUT4 is a mammalian facilitative glucose transporter that is highly expressed in adipose tissue and...
In mammals requiring glucose as a primary energy source for the brain, blood glucose levels are tigh...
Glucose is a monosaccharide and fuel for body, it cannot pass through membrane by simple diffusion s...
AbstractThe glucose transporters (GLUT/SLC2A) are members of the major facilitator superfamily. Here...
helix Cellular uptake of glucose is a tightly controlled process. It is mediated by a family of intr...
BACKGROUND: GLUT4 is a predominant insulin regulated glucose transporter expressed in major glucose ...
GLUT4 is a predominant insulin regulated glucose transporter expressed in major glucose disposal tis...
This article discusses the mechanisms of membrane transport of glucose transporters. Glucose can be ...
Molecular dynamics simulations amounting to ≈8 μs demonstrate that the glucose transporter GLUT1 und...
Facilitative glucose transporters exhibit variable hexose affinity and tissue-specific expression. T...
In mammals, the transport of glucose across cell membranesoccurs by facilitated diffusion. Several c...
Insulin-regulated trafficking of the facilitative glucose transporter GLUT4 has been studied in many...
Despite being one of the first recognized targets of insulin action, the acceleration of glucose tra...
The glucose transporter 1 (GLUT1) belongs to the major facilitator superfamily (MFS) and is responsi...
There are two models of topology for the membrane domains of the erythrocyte/brain facilitative gluc...
GLUT4 is a mammalian facilitative glucose transporter that is highly expressed in adipose tissue and...
In mammals requiring glucose as a primary energy source for the brain, blood glucose levels are tigh...
Glucose is a monosaccharide and fuel for body, it cannot pass through membrane by simple diffusion s...