Oxygen is delivered to brain tissue by a dense network of microvessels, which actively control cerebral blood flow (CBF) through vasodilation and contraction in response to changing levels of neural activity. Understanding these network-level processes is immediately relevant for (1) interpretation of functional Magnetic Resonance Imaging (fMRI) signals, and (2) investigation of neurological diseases in which a deterioration of neurovascular and neuro-metabolic physiology contributes to motor and cognitive decline. Experimental data on the structure, flow and oxygen levels of microvascular networks are needed, together with theoretical methods to integrate this information and predict physiologically relevant properties that are not directl...
Thesis (Ph.D.)--University of Washington, 2019The brain plays a crucial role in life-sustaining acti...
Published in final edited form as: Nat Commun. ; 5: 5734. doi:10.1038/ncomms6734What is the organiz...
This dissertation describes both methodological developments in quantitative functional magnetic res...
Oxygen is delivered to brain tissue by a dense network of microvessels, which actively control cereb...
textBlood flow and its payload of molecular oxygen are two parameters of most physiological interest...
Published in final edited form as: Nat Protoc. 2018 June ; 13(6): 1377–1402. doi:10.1038/nprot.2018...
The cerebral microvascular system is key to a large variety of cerebral processes, including oxygen ...
Departures of normal blood flow and metabolite distribution from the cerebral microvasculature into ...
ABSTRACT: Departures of normal blood flow and metabolite distribution from the cerebral microvascula...
Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding nor...
Oxygen supply to cells by the cardiovascular system involves multiple physical and chemical processe...
The brain accounts for around 2 % of human adult bodyweight but consumes 20 % of the resting oxygen ...
A long-time exposure to lack of oxygen (hypoxia) in some regions of the cerebrovascular system is be...
Healthy brain function depends on continuous blood flow carrying oxygen and metabolites. Ischaemic s...
Recent advances in modeling oxygen supply to cortical brain tissue have begun to elucidate the funct...
Thesis (Ph.D.)--University of Washington, 2019The brain plays a crucial role in life-sustaining acti...
Published in final edited form as: Nat Commun. ; 5: 5734. doi:10.1038/ncomms6734What is the organiz...
This dissertation describes both methodological developments in quantitative functional magnetic res...
Oxygen is delivered to brain tissue by a dense network of microvessels, which actively control cereb...
textBlood flow and its payload of molecular oxygen are two parameters of most physiological interest...
Published in final edited form as: Nat Protoc. 2018 June ; 13(6): 1377–1402. doi:10.1038/nprot.2018...
The cerebral microvascular system is key to a large variety of cerebral processes, including oxygen ...
Departures of normal blood flow and metabolite distribution from the cerebral microvasculature into ...
ABSTRACT: Departures of normal blood flow and metabolite distribution from the cerebral microvascula...
Microscopic in vivo measurements of cerebral oxygenation are of key importance for understanding nor...
Oxygen supply to cells by the cardiovascular system involves multiple physical and chemical processe...
The brain accounts for around 2 % of human adult bodyweight but consumes 20 % of the resting oxygen ...
A long-time exposure to lack of oxygen (hypoxia) in some regions of the cerebrovascular system is be...
Healthy brain function depends on continuous blood flow carrying oxygen and metabolites. Ischaemic s...
Recent advances in modeling oxygen supply to cortical brain tissue have begun to elucidate the funct...
Thesis (Ph.D.)--University of Washington, 2019The brain plays a crucial role in life-sustaining acti...
Published in final edited form as: Nat Commun. ; 5: 5734. doi:10.1038/ncomms6734What is the organiz...
This dissertation describes both methodological developments in quantitative functional magnetic res...