Effects of Sibutramine on the Treatment of Obesity in Patients with Arterial Hypertension
- Alessandra Nunes Faria
- Fernando Flexa Ribeiro Filho
- Daniel Diniz G. Lerário
- Nárcia Kohlmann
- Sandra Roberta Gouvea Ferreira
- Maria Teresa Zanella
DOIAbstract
OBJECTIVE: To assess the effects of weight reduction with 10mg of sibutramine or placebo on blood pressure during 24 hours (ambulatory blood pressure monitoring), on left ventricular mass, and on antihypertensive therapy in 86 obese and hypertensive patients for 6 months. METHODS: The patients underwent echocardiography, ambulatory blood pressure monitoring, and measurement of the levels of hepatic enzymes prior to and after treatment with sibutramine or placebo. RESULTS: The group using sibutramine had a greater weight loss than that using placebo (6.7% versus 2.5%; p<0.001), an increase in heart rate (78.3±7.3 to 82±7.9 bpm; p=0.02), and a reduction in the left ventricular mass/height index (105±29.3 versus 96.6±28.58 g/m; p=0.002). Both ...
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