Add to ORKGA series of novel compounds bearing imidazo[2,1-b]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound N-(6-morpholinopyridin-3-yl)-2-(6-phenylimidazo[2,1-b]thiazol-3-yl)acetamide (5a), and tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. The results indicated that the compound 2-(6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)-N-(6-(4-(4-methoxybenzyl)piperazin-1-yl)pyridin-3-yl)acetamide (5l), with slightly higher inhibition on VEGFR2 than 5a (5.72% and 3.76% inhibitory rate at 20 μM, respectively), was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM) compared with sorafenib (IC50 = 5.2 μM), and showed more selectivity against M...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been design...
[[abstract]]Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazo...
A series of arylidenehydrazide compounds (3a-3j) were synthesized from [6-(4-chlorophenyl)imidazo[2,...
[[abstract]]Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazo...
WOS: 000322181300007In this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-(thiazol-2...
A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been design...
A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been design...
A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and th...
A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and th...
In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophe...
6Heterobivalent ligands constituted by two different pharmacophores that bind to different molecular...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been design...
[[abstract]]Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazo...
A series of arylidenehydrazide compounds (3a-3j) were synthesized from [6-(4-chlorophenyl)imidazo[2,...
[[abstract]]Designed from a high throughput screened hit compound, novel 2-amino-1-thiazolyl imidazo...
WOS: 000322181300007In this work, 2-(4,5-dimethyl-1-(phenylamino)-1H-imidazol-2-ylthio)-N-(thiazol-2...
A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been design...
A series of N-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been design...
A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and th...
A series of novel 2-phenyl-3H-imidazo[4,5-b]pyridines and 2-phenyl-3H-imidazo[4,5-c]pyridines and th...
In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophe...
6Heterobivalent ligands constituted by two different pharmacophores that bind to different molecular...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...
BRAF mutation is commonly known in a number of human cancer types. It is counted as a potential comp...