Comparative study of Lansoprazole and Rabeprazole on ulcer healing property on albino rats

Background: Proton pump inhibitors are widely used for gastroesophageal disorders. The present work was carried out to compare effect of lansoprazole & rabeprozole for gastric ulcer healing. Methods: The study was carried out on gastric ulcer induced by aspirin in albino rats. The rats were divided into control group lansoprazole group and rabeprazole group and the effects of the two drugs, with regards to mean ulcer index was compared with the control and with each other. Analysis of variance and Student’s t-tests were applied to compare the results. Results: It was found that the mean ulcer index varied significantly across the three groups (p = .000). Compared to the control group, the ulcer index was significantly less in both lansoprazole and rabeprazole groups (p = .000). But the ulcer index with rabeprazole was significantly less than that with lansoprazole (p = .001). Conclusion: Rabeprazole is more efficacious than lansoprazole as far as ulcer healing effect is concerned