Prostaglandin (PG) D2 , PGJ2 and Δ12 -PGJ2 are antiproliferative eicosanoids. We investigated the production of PGD2 by murine bone marrow-derived mast cells (BMMC) taking into consideration metabolism of PGD2 to PGD2 and Δ12-PGJ2. PG-metabolites were quantified by high performance liquid chromatography (HPLC) combined with radioimmunoassay (RIA). Stimulated with calcium ionophore A23187 BMMC released eight-fold more PGJ2 and Δ12-PGJ2 than PGD2. Conversion of endogenously produced PGD2 to PGJ2 and Δ12-PGJ2 proceeded rapidly in contrast to metabolism of exogenously added PGD2. The antiproliferative potency of these prostaglandins is demonstrated in vitro. We conclude that determination of PGD2 production by mast cells must take into conside...
A neoplastic mast cell tumor lvas grown in mice wnich had been raised Since birth on a diet enriched...
The current study evaluates the capacity of recombinant rat stem cell factor (rrSCF) to regulate enz...
<p>Bone marrow-derived mast cell (BMMCs) isolated from C57BL/6J mice were evaluated for degranulatio...
Background The major mast cell prostanoid PGD(2) is targeted for therapy of asthma and other disease...
Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast cell...
Cytotoxic action of various prostaglandins (PGs) was examined on the PAM 212 transformed mouse epide...
Prostaglandin D2 (PGD2) is the major cyclooxygenase metabolite of arachidonic acid released after st...
AbstractProstaglandins (PGs) have an important physiological role in the modulation of various cell ...
Prostaglandin (PG) release in cells expressing constitutive cyclooxygenase-1 is known to be regulate...
International audienceGiven that preliminary work has indicated that prostaglandins can play a role ...
Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of pro...
Immunological and biochemical reactions associated with inflammation are elicited in response to a p...
Stimulation of dopamine D2 receptors potentiates Ca2+ ionophore- or ATP-induced arachidonic acid (AA...
PGD2, produced by mast cells, has been detected in high concentrations at sites of allergic inflamma...
Prostaglandin (PG) D2 is the major cyclooxygenase metabolite of arachidonic acid released after immu...
A neoplastic mast cell tumor lvas grown in mice wnich had been raised Since birth on a diet enriched...
The current study evaluates the capacity of recombinant rat stem cell factor (rrSCF) to regulate enz...
<p>Bone marrow-derived mast cell (BMMCs) isolated from C57BL/6J mice were evaluated for degranulatio...
Background The major mast cell prostanoid PGD(2) is targeted for therapy of asthma and other disease...
Prostaglandin D2 PGD2 is a major cyclooxygenase metabolite of arachidonic acid produced by mast cell...
Cytotoxic action of various prostaglandins (PGs) was examined on the PAM 212 transformed mouse epide...
Prostaglandin D2 (PGD2) is the major cyclooxygenase metabolite of arachidonic acid released after st...
AbstractProstaglandins (PGs) have an important physiological role in the modulation of various cell ...
Prostaglandin (PG) release in cells expressing constitutive cyclooxygenase-1 is known to be regulate...
International audienceGiven that preliminary work has indicated that prostaglandins can play a role ...
Inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) results in decreased production of pro...
Immunological and biochemical reactions associated with inflammation are elicited in response to a p...
Stimulation of dopamine D2 receptors potentiates Ca2+ ionophore- or ATP-induced arachidonic acid (AA...
PGD2, produced by mast cells, has been detected in high concentrations at sites of allergic inflamma...
Prostaglandin (PG) D2 is the major cyclooxygenase metabolite of arachidonic acid released after immu...
A neoplastic mast cell tumor lvas grown in mice wnich had been raised Since birth on a diet enriched...
The current study evaluates the capacity of recombinant rat stem cell factor (rrSCF) to regulate enz...
<p>Bone marrow-derived mast cell (BMMCs) isolated from C57BL/6J mice were evaluated for degranulatio...