Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor outcome in HIV-1 pathogenesis. However, the basis of this association remains unclear. Through ex vivo analysis of virus-specific CD8(+) T-cells and the use of an in vitro model of naïve CD8(+) T-cell priming, we show that the activation level and the differentiation state of T-cells are closely related. Acute HIV-1 infection induces massive activation of CD8(+) T-cells, affecting many cell populations, not only those specific for HIV-1, which results in further differentiation of these cells. ...
Immunosenescence is the progressive loss of immune tissue that result from (i) functional, (ii) clon...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the prec...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the prec...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the prec...
The relationship of elevated T cell activation to altered T cell differentiation profiles, each defi...
The relationship of elevated T cell activation to altered T cell differentiation profiles, each defi...
BackgroundThe relationship of elevated T cell activation to altered T cell differentiation profiles,...
BackgroundThe relationship of elevated T cell activation to altered T cell differentiation profiles,...
gression is associated with premature aging of memory CD8+ and CD4+ T cells and naive CD4+ T cells. ...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BackgroundAging-associated noncommunicable comorbidities are more prevalent among human immunodefici...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
Immunosenescence is the progressive loss of immune tissue that result from (i) functional, (ii) clon...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the prec...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the prec...
Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the prec...
The relationship of elevated T cell activation to altered T cell differentiation profiles, each defi...
The relationship of elevated T cell activation to altered T cell differentiation profiles, each defi...
BackgroundThe relationship of elevated T cell activation to altered T cell differentiation profiles,...
BackgroundThe relationship of elevated T cell activation to altered T cell differentiation profiles,...
gression is associated with premature aging of memory CD8+ and CD4+ T cells and naive CD4+ T cells. ...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BackgroundAging-associated noncommunicable comorbidities are more prevalent among human immunodefici...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
Immunosenescence is the progressive loss of immune tissue that result from (i) functional, (ii) clon...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...
BACKGROUND: Aging-associated noncommunicable comorbidities are more prevalent among human immunodefi...