Arvind Kumar1, Tryambak D Singh2, Santosh K Singh3, Satya Prakash41School of Biotechnology, Faculty of Science; 2Department of Medicinal Chemistry, Institute of Medical Sciences; 3Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India; 4Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Physiology, Artificial Cells and Organs Research Centre, Faculty of Medicine, McGill University, Montreal, Québec, CanadaAbstract: This review evaluates methods, success and limitations of transgenes delivery in central nervous system (CNS). Both viral and nonviral (such as liposome mediated) methods, expression and stability of transge...
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system ...
Neural stem cells may present an ideal route for gene therapy as well as offer new possibilities for...
Axons damaged by traumatic injuries are often unable to spontaneously regenerate in the adult centra...
Neurological disorders affecting the central nervous system (CNS) are still incompletely understood....
International audienceFor more than ten years, gene therapy for neurological diseases has experience...
Viral vectors are becoming increasingly important tools to investigate the function of neural protei...
Numerous diseases of the nervous system result from single gene or multifactorial gene defects such ...
Genetic disorders, caused by deleterious changes in the DNA sequence away from the normal genomic se...
Recombinant AAV-mediated gene delivery to the CNS can be performed either by direct delivery at the ...
The delivery of recombinant genes into the brain is becom-ing an increasingly important strategy for...
Gene therapies hold great promise for the treatment of many neurodegenerative disorders and traumati...
International audienceBackground: Gene delivery within the central nervous system at postnatal age i...
The past few years have seen rapid advancements in vector-mediated gene transfer to the nervous syst...
Gene therapy in the brain is a promising treatment strategy that in the future may be used for sever...
Direct in vivo gene transfer to the central nervous system (CNS) using recombinant lentiviral vector...
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system ...
Neural stem cells may present an ideal route for gene therapy as well as offer new possibilities for...
Axons damaged by traumatic injuries are often unable to spontaneously regenerate in the adult centra...
Neurological disorders affecting the central nervous system (CNS) are still incompletely understood....
International audienceFor more than ten years, gene therapy for neurological diseases has experience...
Viral vectors are becoming increasingly important tools to investigate the function of neural protei...
Numerous diseases of the nervous system result from single gene or multifactorial gene defects such ...
Genetic disorders, caused by deleterious changes in the DNA sequence away from the normal genomic se...
Recombinant AAV-mediated gene delivery to the CNS can be performed either by direct delivery at the ...
The delivery of recombinant genes into the brain is becom-ing an increasingly important strategy for...
Gene therapies hold great promise for the treatment of many neurodegenerative disorders and traumati...
International audienceBackground: Gene delivery within the central nervous system at postnatal age i...
The past few years have seen rapid advancements in vector-mediated gene transfer to the nervous syst...
Gene therapy in the brain is a promising treatment strategy that in the future may be used for sever...
Direct in vivo gene transfer to the central nervous system (CNS) using recombinant lentiviral vector...
Lentiviral vectors have been used extensively as gene transfer tools for the central nervous system ...
Neural stem cells may present an ideal route for gene therapy as well as offer new possibilities for...
Axons damaged by traumatic injuries are often unable to spontaneously regenerate in the adult centra...