Striatal nitric oxide (NO)-producing interneurons play an important role in the regulation of corticostriatal synaptic transmission and motor behavior. Striatal NO synthesis is driven by concurrent activation of NMDA and dopamine (DA) D1 receptors. NO diffuses into the dendrites of medium-sized spiny neurons (MSNs) which contain high levels of NO receptors called soluble guanylyl cyclases (sGC). NO-mediated activation of sGC leads to the synthesis of the second messenger cGMP. In the intact striatum, transient elevations in intracellular cGMP primarily act to increase neuronal excitability and to facilitate glutamatergic corticostriatal transmission. NO-cGMP signaling also functionally opposes the inhibitory effects of DA D2 receptor activ...
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl ...
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl ...
Conflicting data have been collected so far on the action of nitric oxide (NO) on cholinergic intern...
ithin the striatum, the gaseous neurotransmitter nitric oxide (NO) is produced by a subclass of inte...
Several recent studies have emphasized a crucial role for the nitrergic system in movement control a...
Striatal medium-sized spiny neurons (MSNs) contain the highest levels of soluble guanylyl cyclase (s...
Nitric oxide (NO) is a pleiotropic molecule that is needed for physiological functions, especially i...
Several recent studies have emphasized a crucial role for the nitrergic system in movement control a...
© 2014 Elsevier Inc. Nitric oxide (NO), a gaseous messenger molecule synthesized by nitric oxide syn...
There is evidence suggesting that nitric oxide (NO) may play an important role in dopamine (DA) cell...
Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular messeng...
International audienceThe NO-cGMP signaling plays an important role in the regulation of striatal fu...
By using multi-probe microdialysis we previously demonstrated that endogenous glutamate differential...
Parkinson's disease (PD) is a progressive neurodegenerative disorder of unclear etiology and pathoge...
The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a cr...
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl ...
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl ...
Conflicting data have been collected so far on the action of nitric oxide (NO) on cholinergic intern...
ithin the striatum, the gaseous neurotransmitter nitric oxide (NO) is produced by a subclass of inte...
Several recent studies have emphasized a crucial role for the nitrergic system in movement control a...
Striatal medium-sized spiny neurons (MSNs) contain the highest levels of soluble guanylyl cyclase (s...
Nitric oxide (NO) is a pleiotropic molecule that is needed for physiological functions, especially i...
Several recent studies have emphasized a crucial role for the nitrergic system in movement control a...
© 2014 Elsevier Inc. Nitric oxide (NO), a gaseous messenger molecule synthesized by nitric oxide syn...
There is evidence suggesting that nitric oxide (NO) may play an important role in dopamine (DA) cell...
Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular messeng...
International audienceThe NO-cGMP signaling plays an important role in the regulation of striatal fu...
By using multi-probe microdialysis we previously demonstrated that endogenous glutamate differential...
Parkinson's disease (PD) is a progressive neurodegenerative disorder of unclear etiology and pathoge...
The striatum contains a rich variety of cyclic nucleotide phosphodiesterases (PDEs), which play a cr...
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl ...
Impaired NO-cGMP signaling has been linked to several neurological disorders. NO-sensitive guanylyl ...
Conflicting data have been collected so far on the action of nitric oxide (NO) on cholinergic intern...