Abstract Background Proopiomelanocortin (POMC)-derived beta-endorphin1-31 from immune cells can inhibit inflammatory pain. Here we investigated cytokine signaling pathways regulating POMC gene expression and beta-endorphin production in lymphocytes to augment such analgesic effects. Results Interleukin-4 dose-dependently elevated POMC mRNA expression in naïve lymph node-derived cells in vitro, as determined by real-time PCR. This effect was neutralized by janus kinase (JAK) inhibitors. Transfection of Signal Transducer and Activator of Transcription (STAT) 1/3 but not of STAT6 decoy oligonucleotides abolished interleukin-4 induced POMC gene expression. STAT3 was phosphorylated in in vitro interleukin-4 stimulated lymphocytes and in lymph no...
Abstract: When tissue is destroyed or invaded by leukocytes in inflammation, numerous mediators are ...
Peripheral immune cell-mediated analgesia in inflammation is an important endogenous mechanism of pa...
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors con...
1. Recent findings have suggested a significant involvement of the immune system in the control of p...
Localized inflammation of a rat's hindpaw elicits an accumulation of beta-endorphin-(END) containing...
International audienceLocalized inflammation of a rat's hindpaw elicits an accumulation of beta-endo...
Background Leukocytes containing opioid peptides locally control inflammatory pain. In the early ...
Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evid...
Background: T cell-derived opioids play a key role in the control of inflammatory pain. However, the...
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed tissue, an ...
The functional integrity of the immune system is essential for peripheral antinociception. Previous ...
International audienceAbstractBackgroundT cell-derived opioids play a key role in the control of inf...
In inflammation, leucocytes containing opioid peptides migrate into the tissue. Opioid peptides can ...
Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pain, but ...
<div><p>Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pa...
Abstract: When tissue is destroyed or invaded by leukocytes in inflammation, numerous mediators are ...
Peripheral immune cell-mediated analgesia in inflammation is an important endogenous mechanism of pa...
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors con...
1. Recent findings have suggested a significant involvement of the immune system in the control of p...
Localized inflammation of a rat's hindpaw elicits an accumulation of beta-endorphin-(END) containing...
International audienceLocalized inflammation of a rat's hindpaw elicits an accumulation of beta-endo...
Background Leukocytes containing opioid peptides locally control inflammatory pain. In the early ...
Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evid...
Background: T cell-derived opioids play a key role in the control of inflammatory pain. However, the...
Peripheral mechanisms of endogenous pain control are significant. In peripheral inflamed tissue, an ...
The functional integrity of the immune system is essential for peripheral antinociception. Previous ...
International audienceAbstractBackgroundT cell-derived opioids play a key role in the control of inf...
In inflammation, leucocytes containing opioid peptides migrate into the tissue. Opioid peptides can ...
Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pain, but ...
<div><p>Acupuncture is widely used for pain treatment in patients with osteoarthritis or low back pa...
Abstract: When tissue is destroyed or invaded by leukocytes in inflammation, numerous mediators are ...
Peripheral immune cell-mediated analgesia in inflammation is an important endogenous mechanism of pa...
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors con...