The inter-annual variability of Adriatic Sea hydrographic characteristics is investigated by means of numerical simulation and direct observation. The period under investigation runs from the beginning of 2000 to the end of 2008. The model used to carry out the simulation is derived from the primitive equation component of the Adriatic Forecasting System (AFS). The model is based on the Princeton Ocean Model (POM) adapted in order to reproduce the features of the Adriatic. Both numerical findings and observations agree in depicting a strong inter-annual variability in the entire Adriatic Sea and its sub-basins. Nevertheless, two model deficiencies are identified: an excessive vertical/horizontal mixing and an inaccurate representation of th...