原发性胆汁性肝硬化中B细胞免疫的研究进展

Primary biliary cirrhosis (PBC) is characterized by injury of small intrahepatic bile ducts, but its mechanism, especially the role of B cell immunity in this disease, remains unclear. The possible role of B cell immunity in the pathogenesis of PBC is reviewed from the following aspects: distribution of B cells and plasma cells in the liver tissues of PBC patients, clearance of B cells, mechanism of abnormal increase in serum IgM and its sources among PBC patients, mechanism of production of antimitochondrial antibodies and their possible functions in bile duct injury, and typical autoantibodies in PBC. B cell immunity is considered to play a significant role in the pathogenesis of PBC, but there are still many key problems to be clarified