Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have been subjected to an interdisciplinary study since the seventies, when Dr. Benjamin Gilbert, at the Federal University of Rio de Janeiro, launched a program on the chemistry of natural products active against endemic diseases. In this paper we describe the synthesis of five naphthoimidazoles, derived from this program and their activity towards T. cruzi, the etiologic agent of Chagas disease. We also review the influence of chemical structure on trypanocidal action of naphthoquinones and of derived heterocycles with imidazole, oxazole, phenoxazine, indole, dipyrane and cyclopentene rings. The overall analysis corroborates the tendency of trypan...
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones,...
AbstractIn our continued search for novel trypanocidal compounds, twenty-six derivatives of para- an...
Derivatives of natural quinones with biological activities, such as lapachol, α- and β-lapachones, h...
Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have be...
Naphthoquinones are compounds present in several families of higher plants. Their molecular structur...
Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma...
A doença de Chagas causada pelo Trypanosoma cruzi afeta cerca de oito milhões de pessoas em países e...
AbstractIn our continued search for novel trypanocidal compounds, twenty-six derivatives of para- an...
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones,...
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones,...
AbstractIn our continued search for novel trypanocidal compounds, twenty-six derivatives of para- an...
Derivatives of natural quinones with biological activities, such as lapachol, α- and β-lapachones, h...
Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have be...
Naphthoquinones are compounds present in several families of higher plants. Their molecular structur...
Chagas disease is one of the most important endemic diseases in Latin America, caused by Trypanosoma...
A doença de Chagas causada pelo Trypanosoma cruzi afeta cerca de oito milhões de pessoas em países e...
AbstractIn our continued search for novel trypanocidal compounds, twenty-six derivatives of para- an...
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones,...
To develop novel chemotherapeutic alternatives for the treatment of Chagas disease, in this study, a...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Naphtho[2,3-b]thiophen-4,9-quinone and five derivatives were prepared using the Friedel-Crafts react...
Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones,...
AbstractIn our continued search for novel trypanocidal compounds, twenty-six derivatives of para- an...
Derivatives of natural quinones with biological activities, such as lapachol, α- and β-lapachones, h...