This article aims to defend Locke against Quine’s charge, made in his famous “two dogmas” paper, that Locke’s theory of knowledge is badly flawed, not only for assuming the dogmas, but also for adopting an “in-tolerably restrictive” version of the dogma of reductionism. It is shown here that, in his analysis of the epistemological status of scientific laws, Locke has effectively transcended the narrow idea-empiricism which un-derlies this version of reductionism. First, in order to escape idealism, he introduced the notion of “sensitive knowledge of the particular existence of finite beings without us,” broadening thus his initial definition of knowledge in terms of the “perception of the agreement or disagreement of ideas” — a definition c...