Abstract Remodelling of mitochondrial metabolism is a hallmark of cancer. Mutations in the genes encoding succinate dehydrogenase (SDH), a key Krebs cycle component, are associated with hereditary predisposition to pheochromocytoma and paraganglioma, through mechanisms which are largely unknown. Recently, the jumonji-domain histone demethylases have emerged as a novel family of 2-oxoglutarate-dependent chromatin modifiers with credible functions in tumourigenesis. Using pharmacological and siRNA methodologies we show that increased methylation of histone H3 is a general consequence of SDH loss-of-function in cultured mammalian cells and can be reversed by overexpression of the JMJD3 histone demethylase. ChIP analysis revealed that the core ...
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochond...
AbstractThe SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; m...
International audienceThe genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as t...
Item does not contain fulltextSuccinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarbo...
BackgroundSuccinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both...
BackgroundSuccinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both...
SummaryParagangliomas are neuroendocrine tumors frequently associated with mutations in RET, NF1, VH...
AbstractGerm line heterozygous mutations in the structural subunit genes of mitochondrial complex II...
ABSTRACT Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduc-tion kina...
BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic aci...
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé a...
<div><p>Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the ...
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheo...
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique...
Succinate dehydrogenase (SDH) mutations lead to the accumulation of succinate, which acts as an onco...
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochond...
AbstractThe SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; m...
International audienceThe genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as t...
Item does not contain fulltextSuccinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarbo...
BackgroundSuccinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both...
BackgroundSuccinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both...
SummaryParagangliomas are neuroendocrine tumors frequently associated with mutations in RET, NF1, VH...
AbstractGerm line heterozygous mutations in the structural subunit genes of mitochondrial complex II...
ABSTRACT Gastrointestinal stromal tumors (GIST) harbor driver mutations of signal transduc-tion kina...
BACKGROUND: Mitochondrial succinate dehydrogenase (SDH) is a component of both the tricarboxylic aci...
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé a...
<div><p>Familial paraganglioma (PGL) is a rare neuroendocrine cancer associated with defects in the ...
Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheo...
Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme with the unique...
Succinate dehydrogenase (SDH) mutations lead to the accumulation of succinate, which acts as an onco...
The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochond...
AbstractThe SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; m...
International audienceThe genes encoding succinate dehydrogenase (SDH) subunits B, C and D, act as t...