Abstract Background Differentiation-inducing factor-1 (DIF-1) is a putative morphogen that induces cell differentiation in Dictyostelium discoideum. DIF-1 inhibits proliferation of various mammalian tumor cells by suppressing the canonical Wnt/β-catenin signaling pathway. To assess the potential of a novel cancer chemotherapy based on the pharmacological effect of DIF-1, we investigated whether DIF-1 exhibits anti-angiogenic effects in vitro and in vivo. Results DIF-1 not only inhibited the proliferation of human umbilical vein endothelial cells (HUVECs) by restricting cell cycle in the G0/G1 phase and degrading cyclin D1, but also inhibited the ability of HUVECs to form capillaries and migrate. Moreover, DIF-1 suppressed VEGF- and cancer c...
Endostar, a novel modified recombinant human endostatin, is now widely studied for the treatment of ...
[[abstract]]Anti-angiogenesis therapy is one major approach of cancer therapies nowadays. Unfortunat...
Abstract Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect o...
As angiogenesis is required for tumor growth and metastasis, suppressing angiogenesis is a promising...
Aberrant activation of Wnt signaling plays an important role in hepatocarcinogenesis. In addition to...
OBJECTIVE To determine the role of Wnt antagonist Dickkopf (DKK) 1 in human endothelial colony-formi...
Different mechanisms of angiogenesis and vasculogenesis are involved in the development of the tumor...
Background and PurposeAngiogenesis contributes to coronary heart disease, immune disorders and numer...
The association between angiogenesis and chronic inflammatory diseases, such as psoriasis, seems to ...
Abstract Background Recent studies suggested that cancer stem-like cells contribute to tumor vasculo...
Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-ex...
In order to grow beyond minimal size and to metastasize, tumors need to induce the growth of new blo...
Vascular endothelial growth factor (VEGF) signaling is critical for tumor angiogenesis. However, the...
Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel growth. ...
Angiogenesis is defined as the development of blood vessels from a pre-existing vasculature and has ...
Endostar, a novel modified recombinant human endostatin, is now widely studied for the treatment of ...
[[abstract]]Anti-angiogenesis therapy is one major approach of cancer therapies nowadays. Unfortunat...
Abstract Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect o...
As angiogenesis is required for tumor growth and metastasis, suppressing angiogenesis is a promising...
Aberrant activation of Wnt signaling plays an important role in hepatocarcinogenesis. In addition to...
OBJECTIVE To determine the role of Wnt antagonist Dickkopf (DKK) 1 in human endothelial colony-formi...
Different mechanisms of angiogenesis and vasculogenesis are involved in the development of the tumor...
Background and PurposeAngiogenesis contributes to coronary heart disease, immune disorders and numer...
The association between angiogenesis and chronic inflammatory diseases, such as psoriasis, seems to ...
Abstract Background Recent studies suggested that cancer stem-like cells contribute to tumor vasculo...
Angiogenesis is a normal biological process wherein new blood vessels form from the growth of pre-ex...
In order to grow beyond minimal size and to metastasize, tumors need to induce the growth of new blo...
Vascular endothelial growth factor (VEGF) signaling is critical for tumor angiogenesis. However, the...
Many proliferative diseases, most typically cancer, are driven by uncontrolled blood vessel growth. ...
Angiogenesis is defined as the development of blood vessels from a pre-existing vasculature and has ...
Endostar, a novel modified recombinant human endostatin, is now widely studied for the treatment of ...
[[abstract]]Anti-angiogenesis therapy is one major approach of cancer therapies nowadays. Unfortunat...
Abstract Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect o...