New acquisitions in treating infection due to necrotic pancreatitis: prevention or cure?

  • Raffaele Pezzilli
  • Bahjat Barakat
Publication date
June 2008
Publisher
PAGEPress Publications
Journal
Emergency Care Journal

Abstract

Early antibiotic treatment is still a therapeutic challenge in the clinical management of acute necrotic pancreatitis. The antibiotic of choice for the prevention of the infection of necrotic pancreatic tissue would appear to be imipenem and, more recently, meropenem has also been suggested. The latter belongs to the same family of antibiotics as imipenem but delivers greater stability in the presence of renal dehydropeptidase-I and an increase in activity against gram-negative bacteria, it offers similar efficacy to imipenem in preventing pancreatic infection and extrapancreatic infections when associated with severe acute pancreatitis. Two further studies have advised against prophylactic use of antibiotics in the prevention of acute necr...

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