Abstract Background Worldwide, millions of people are treated each year for significant head injury. A substantial proportion die, and many more are disabled. If short term corticosteroid infusion could be reliably shown to reduce these risks by just a few percent then this might affect the treatment of a few hundred thousand patients a year, protecting thousands from death or long term disability. Study design CRASH is a large simple, placebo-controlled trial of the effects of a 48-hour infusion of corticosteroids on death and on neurological disability, among adults with head injury and some impairment of consciousness. Head injured patients with impaired consciousness who are judged to be 16 years or older are eligible if the responsible...
The CRASH3 results are out, but do we know what to do? The study enrolled 9202 head injured patients...
Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...
BACKGROUND: Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the r...
BACKGROUND: Worldwide, millions of people are treated each year for significant head injury. A subst...
A large simple placebo controlled trial, among adults with head injury and impaired consciousness, o...
CRASH (Corticosteroid randomisation after significant head injury) is a prospective multi-centre ran...
OBJECTIVES: To test the design and feasibility of a large scale multicentre randomised controlled tr...
The global epidemic of head injuries is just beginning. Many are caused by road traffic crashes. It ...
BACKGROUND: Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, f...
MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on deat...
MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on deat...
Methylprednisolone was associated with an increase in death after head injury CRASH Trial Collaborat...
In the past, corticosteroids were given to head-injured patients in order to prevent secondary brain...
Abstract Background Worldwide, over 10 million people are killed or hospitalized because of traumati...
Abstract Background Traumatic brain injury (TBI) is a main cause of severe prolonged disability of y...
The CRASH3 results are out, but do we know what to do? The study enrolled 9202 head injured patients...
Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...
BACKGROUND: Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the r...
BACKGROUND: Worldwide, millions of people are treated each year for significant head injury. A subst...
A large simple placebo controlled trial, among adults with head injury and impaired consciousness, o...
CRASH (Corticosteroid randomisation after significant head injury) is a prospective multi-centre ran...
OBJECTIVES: To test the design and feasibility of a large scale multicentre randomised controlled tr...
The global epidemic of head injuries is just beginning. Many are caused by road traffic crashes. It ...
BACKGROUND: Corticosteroids have been used to treat head injuries for more than 30 years. In 1997, f...
MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on deat...
MRC CRASH is a randomised controlled trial (ISRCTN74459797) of the effect of corticosteroids on deat...
Methylprednisolone was associated with an increase in death after head injury CRASH Trial Collaborat...
In the past, corticosteroids were given to head-injured patients in order to prevent secondary brain...
Abstract Background Worldwide, over 10 million people are killed or hospitalized because of traumati...
Abstract Background Traumatic brain injury (TBI) is a main cause of severe prolonged disability of y...
The CRASH3 results are out, but do we know what to do? The study enrolled 9202 head injured patients...
Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...
BACKGROUND: Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the r...