Local discrete elevations in myoplasmic Ca2+ (Ca2+ sparks) arise from the opening of a small group of RyRs. Summation of a large number of Ca2+ sparks gives rise to the whole cell Ca2+ transient necessary for muscle contraction. Unlike sarcoplasmic reticulum vesicle preparations and isolated single channels in artificial membranes, the study of Ca2+ sparks provides a means to understand the regulation of a small group of RyRs in the environment of a functionally intact triad and in the presence of endogenous regulatory proteins. To gain insight into the mechanisms that regulate the gating of RyRs we have utilized laser scanning confocal microscopy to measure Ca2+ sparks in permeabilized frog skeletal muscle fibers. This review summarizes ou...
International audienceCa2+ sparks, the elementary units of sarcoplasmic reticulum (SR) Ca2+ release ...
LA. Ca2 entry-independent effects of L-type Ca2 channel modula-tors on Ca2 sparks in ventricular ...
Calcium sparks represent local, rapid, and transient calcium release events from a cluster of ryanod...
AbstractCalmodulin is a ubiquitous Ca2+ sensing protein that binds to and modulates the sarcoplasmic...
In cardiac muscle and amphibian skeletal muscle, the intracellular Ca2+ release that signals contrac...
AbstractWe have investigated the effects of imperatoxin A (IpTxa) on local calcium release events in...
Ca2+ sparks are localized intracellular Ca2+ release events from the sarcoplasmic reticulum in muscl...
Most excitable cells maintain tight control of intracellular Ca2+ through coordinated interaction be...
Ca2+ ions passing through a single or a cluster of Ca2+-permeable channels create microscopic, short...
Calcium release during skeletal muscle excitation-contraction (EC) coupling occurs at the junctions ...
Skeletal muscle fibres are large and highly elongated cells specialized for producing the force requ...
Ca(2+) sparks are highly localized Ca(2+) transients caused by Ca(2+) release from sarcoplasmic reti...
Stimuli are translated to intracellular calcium signals via opening of inositol trisphosphate recept...
Experiments were performed to characterize the properties of the intrinsic Ca2+\ua0buffers in the sa...
Calcium release through ryanodine receptors (RYR) activates calcium-dependent membrane conductances ...
International audienceCa2+ sparks, the elementary units of sarcoplasmic reticulum (SR) Ca2+ release ...
LA. Ca2 entry-independent effects of L-type Ca2 channel modula-tors on Ca2 sparks in ventricular ...
Calcium sparks represent local, rapid, and transient calcium release events from a cluster of ryanod...
AbstractCalmodulin is a ubiquitous Ca2+ sensing protein that binds to and modulates the sarcoplasmic...
In cardiac muscle and amphibian skeletal muscle, the intracellular Ca2+ release that signals contrac...
AbstractWe have investigated the effects of imperatoxin A (IpTxa) on local calcium release events in...
Ca2+ sparks are localized intracellular Ca2+ release events from the sarcoplasmic reticulum in muscl...
Most excitable cells maintain tight control of intracellular Ca2+ through coordinated interaction be...
Ca2+ ions passing through a single or a cluster of Ca2+-permeable channels create microscopic, short...
Calcium release during skeletal muscle excitation-contraction (EC) coupling occurs at the junctions ...
Skeletal muscle fibres are large and highly elongated cells specialized for producing the force requ...
Ca(2+) sparks are highly localized Ca(2+) transients caused by Ca(2+) release from sarcoplasmic reti...
Stimuli are translated to intracellular calcium signals via opening of inositol trisphosphate recept...
Experiments were performed to characterize the properties of the intrinsic Ca2+\ua0buffers in the sa...
Calcium release through ryanodine receptors (RYR) activates calcium-dependent membrane conductances ...
International audienceCa2+ sparks, the elementary units of sarcoplasmic reticulum (SR) Ca2+ release ...
LA. Ca2 entry-independent effects of L-type Ca2 channel modula-tors on Ca2 sparks in ventricular ...
Calcium sparks represent local, rapid, and transient calcium release events from a cluster of ryanod...